Most significant discoveries
His most significant contributions are in the areas of Biosciences,
Biotechnologies
e Nanotechnologies, with the exception in his early life as nuclear
physicist,for
the discovery with the Cambridge Group Padova-Mit-Harvard of the
branching
ratios of eta zero meson (Nuc. Instrum. and meth., 1971, 91,
589-598
- Physics Letters, 1975, 568-487-490 Nuovo Cimento,
1974,
21A, 387-413), which establishes its quantum numbers.
Namely:
-
the discovery and clarification of the quaternary DNA structure
in the
human genome (Science, 1976, 192, 796-798 - Phys. Chem.
Phys.,
1976 - J. Mol. Biol., 1982, 161, 155-175), until the
identification
of the structural subunit called fibrosome ( and later on by other
loop),
associated to the single gene (Science, 1982, 219, 176-179 - J.
Cell Science 1983), suggesting first in 50.000 the maximum number
of
genes in human cells (AntiCancer Research, 3, 63-86, 1983);
-
the discovery of histones enzymatic modifications and of
non-histones
loosily bound to DNA, extractable at 0,35 M (P.N.A.S. USA,
1975,
72, 2361-2365) and clarification of their role in the control of cell
function(Biochemistry,
1979, 18, 1333-1345) and of nucleosome structure (Biochemistry,
1993, 32, 6465-75);
-
a new characterization of the cell cycle (Science,
1977,
196, 1106-1109, Biophysical J., 1977, 19, 163-176);
-
identification and characterization of non proliferating non
proliferating
GO e Q cells (Nature, 1977, 270, 163-176, Exp. Cell. Res.,
1977, 106, 118-127).
He has been momg the pioneers:
-
cell laser microfluorimetry (Cancer Treat. Rep.,
1976, 60,
1819-1827);
-
cell image analysis (Cytometry 2, 1982, 2, 407-431,Exp.
Cell. Res., 1977, 106, 118-127 - Biophysical J., 1977, 19,
163-176),
which opened new horizons in modern Medicine;
-
complex biomathematical models and pharmaco-enzymatic (Bioch.
Pharm., 1979, 28, 2891-2908);
-
pharmaco-kinetic aied to cancer (Bioph. Bioch. Acta rev.
cancer,
1976, 458, 243-282).
He discovered the differential scattering polarized circular light (Phys.
Chem., 1975, Science, 1975, Biopolymers, 1979),
with
application to defense and medicine.
He solved the 3D atomic structure of histone H1 (Quart. of Magn.
Res. in Biol. and Med., 2, 83-97, 1995), and the software for
automatic
sequential NMR assignemet of amino-acids (J. Comp. Chem., 1990,
11, 805-818).
In most recent times he has been among the pioneers internationally
of Bioelettronics and Nanotechnologiestowards the biochip and the
biocomputer
(Biosensors and Bioelectronics, 10, 105-127, 1995) through the
development
of:
-
new monoelectronic device operating at room temperature (Proceeding
National Academy of Sciences USA 93, 10556-10559, 1996);
-
new sensors (Physics World, 1992, 5, 5, Sensor
and Actuators,
1992, 7, 343; 1994, B18, 178-182), SPM (Review Scientific Instruments,
65, 2860-63, 1994, and 71, 1-5, 2000);
-
materials (Thin Solid Films, 1994; Material
Science and
Engineering 3, 13-21, 21-23, 33-38 1995);
-
nanocatalisys (Trends in Biotechnology, 15, 395-401,
1997);
-
biomolecolar devices (Physical Review Letter, 1994, J.
Applied Physics, 75, 4000-4008, 1994; Thin Solid Film, 230,
86-89, 1993);
-
developping new LB e LS thin film technologies to obtain to
heat-proof
proteins (Biochimica Biophysica Acta, 1993, 1158, 273-278; Langmuir
11, 2719-2725, 1995),
-
lipids (Material Science and Engineering, 1994),
-
fatty acids (Journal of Physical Chemistry, 98,
13323-13327,
1994),
-
organic materials (Synthetic Metals, 74, 1-6, 1995)
-
conductive polymers (Nanotechnology
2000; Polymers 2000)
- organic batteries (Analytica Chimica Acta, 2006)
- organic nanotechnology (Macromolecules 2005, Nanotechnology 2006)
- DNA chip (J. Cell. Biochem. 2006)
- APA (Nanotechnology 2006)
- nanocrystallography (Trends in Biotechnology 2004, Acta Crystallographyca 2003 ,2004,
2005)
Numerous patents resulted:
-
Adami M., Nicolini C., PAB Biosensor Pat. App. No. GB 9324258.4;
-
Erokhin V. Nicolini C., Metal Sulfide Film, Pat. App. No. RM94A000097;
-
Nicolini C., Protein Thermal Stabilization, Pat. App. No.GB 9324327.7;
-
Adami M., Nicolini C., Redox Biosensor Pat. App. No. GB 9411059.0;
-
NicoliniC., Biosensor Chemotherapy Pat. App. No.GB 9411072.3;
-
Paddeu S. Nicolini C., LB Film/Pesticide Detection Pat. App. No.GB
9411065.7;
-
Paddeu S., Nicolini C., PAB as Immunosensor Pat. App. No.GB 9414189.2;
-
Nicolini C., Gravimetric Immunosensor Pat. App. No.GB 9414190.0;
-
Antolini F., Nicolini C., Protein Functionalization Pat. App.
N.RM94000484;
-
Troitsky V., Nicolini C., LB Trough Pat. App. No.GB 9418069.2;
-
Erokhin V., Nicolini C., Single Electron Element Pat. App. No.GB
9500669.8;
-
Erokhin. V., and Nicolini C., Thin film/Reverse Micelles Pat. App. No.
RM93A000659, PCT/IB94/00307;
-
Sartore M., Nicolini C., Non-Linear Control for Peltier-based
Thermostat
Pat. App. No. RM93A000846.
Other last few years relevant oublications are:
-
Ding H., Ram M.K., Nicolini C., Synthetic Metals 118, 81-88,
2001.
-
Nicolini C., Erokhin V., Ghisellini P., Paternolli C., Ram M.K.,
Sivozhelezov
V., Langmuir 17, 3719-3726, 2001.
-
Ram M.K., Sarkar N., Ding H., Nicolini C., Synthetic Metals,
123,
197-206, 2001.
-
M.K. Ram, P. Bertoncello, C. Nicolini, Electroanalysis, 13,
574-581,
2001.
-
Ram M.K., Sarkar N., Bertoncello P., Sarkara A., Narizzano R., Nicolini
C., Synthetic Metals 122, 369-378, 2001.
-
Ding H., Ram M.K., Nicolini C., Journal of Nanoscience and
Nanotechnology
1, 207-213, 2001.
-
Pechkova E., Nicolini C. Journal of Crystal Growth 231,
599-602,
2001.
-
Sartore M., Pace R., Faraci P., Nardelli D., Adami M., Ram M.K.,
Nicolini
C., Rev. Sci. Instrum. 71,1-5, 2000.
-
M.K. Ram, M. Adami, P. Faraci, C. Nicolini, Polymer 41,
7499-7505,
2000.
-
N. Sarkar, M. K. Ram, A. Sarkar, R. Narizzano, S. Paddeu, C. Nicolini,
Nanotechnology,
11, 30-36, 2000.
-
M.K. Ram, M. Adami, S. Paddeu, C. Nicolini, Nanotechnology 11,
112-119,
2000.
-
Carrara S., Erokhin V., Nicolini C., Langmuir 16, 6577-6582,
2000.
-
Ding H., Erokhin V., Ram M.K., Paddeu S., Nicolini C., Materials
Science
Engineering C 11, 121-128, 2000.
-
Ding H., Erokhin V., Ram M.K., Paddeu S., Valkova L., Nicolini C., Thin
Solid Films 379, 279-286, 2000.
-
Ram M.K., Nicolini C. Recent Reserch Development in Physical
Chemistry,
TransWorld Publishing, 4, 219-258, 2000.
-
M.K. Ram, N. Sarkar, P. Bertoncello, A. Sarkar, R. Narizzano, C.
Nicolini,
Synthetic
Metals 7638, 1-10, 2000.
-
Nicolini C., Erokhin V., Paddeu S., Paternolli C., Ram M.K., Biosensors
& Bioelectronics 14, 427-433, 1999.
-
Ram M.K., Salerno M., Adami M., Faraci P., Nicolini C., Langmuir
15, 1252-1259, 1999.
-
Ram M.K., Adami M., Salerno S., Paddeu S., Nicolini C., Synthetic
Metals
100, 249-259, 1999.
-
Salerno M., Sartore M., Nicolini C., Probe Microscopy 1,
333-334,
1999.
-
Vergani L., Fugazza G., Chessa L., Nicolini C., Journal of Cellular
Biochemistry 75, 578-586, 1999.
-
Notargiacomo A., Foglietti V., Cianci E., Capellini G., Adami M.,
Faraci
P., Evangelisti F., Nicolini C., Nanotechnology 10, 458-463,
1999.
-
Nicolini C., Erokhin V., Facci P., Rossi A., Guerzoni S., Paschkevitch
P., Biosensors& Bioelectronics 12, 613-618 1997.
-
Facci P., Erokhin V.,Nicolini C., PNAS USA 93, 10556-10559,
1996.
-
Nicolini C., Annals New York Academy of Sciences
799,297-311,1996.